|
Symbol Name ID |
Jak2
Janus kinase 2 MGI:96629 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormal bleeding |
Epistaxis |
Gastrointestinal hemorrhage |
Cerebral hemorrhage |
Prolonged bleeding time |
Bruising susceptibility |
Purpura |
Abnormal bone marrow cell morphology |
Abnormal megakaryocyte morphology |
Increased megakaryocyte count |
Increased micromegakaryocyte count |
Increased multinucleated megakaryocyte count |
Megakaryocyte nucleus hyperlobulation |
Myelofibrosis |
Increased hematocrit |
Abnormal hemoglobin |
Increased circulating hemoglobin concentration |
Polycythemia |
Increased red blood cell mass |
Leukocytosis |
Hemophagocytosis |
Acute leukemia |
Acute myeloid leukemia |
Chronic myelogenous leukemia |
Myeloproliferative disorder |
Abnormal thrombosis |
Arterial thrombosis |
Peripheral thrombosis |
Thromboembolism |
Venous thrombosis |
Hepatic vein thrombosis |
Abnormality of thrombocytes |
Impaired ADP-induced platelet aggregation |
Impaired collagen-induced platelet aggregation |
Impaired epinephrine-induced platelet aggregation |
Abnormal platelet morphology |
Thrombocytopenia |
Thrombocytosis |
Extramedullary hematopoiesis |
Myelodysplasia |
Splenomegaly |
| Disease(s) Associated with JAK2 | |||||||||||||||||||||||||||||||||||||||||
| acute myeloid leukemia | |||||||||||||||||||||||||||||||||||||||||
| essential thrombocythemia | |||||||||||||||||||||||||||||||||||||||||
| familial erythrocytosis 1 | |||||||||||||||||||||||||||||||||||||||||
| myelofibrosis | |||||||||||||||||||||||||||||||||||||||||
| polycythemia vera |
| Mouse Phenotypes | hematopoietic system phenotype |
abnormal megakaryocyte differentiation |
abnormal embryonic erythropoiesis |
enlarged spleen |
increased spleen weight |
abnormal definitive hematopoiesis |
abnormal common myeloid progenitor cell morphology |
absent common myeloid progenitor cells |
abnormal erythropoiesis |
abnormal myelopoiesis |
myeloid hyperplasia |
extramedullary hematopoiesis |
anemia |
impaired hematopoiesis |
abnormal bone marrow cell morphology/development |
decreased bone marrow cell number |
abnormal megakaryocyte morphology |
increased megakaryocyte cell number |
decreased erythroid progenitor cell number |
increased erythroid progenitor cell number |
increased megakaryocyte progenitor cell number |
decreased erythroblast number |
abnormal erythrocyte morphology |
decreased erythrocyte cell number |
increased erythrocyte cell number |
polycythemia |
decreased hematocrit |
increased hematocrit |
decreased hemoglobin content |
increased hemoglobin content |
decreased mean corpuscular volume |
anisocytosis |
increased number of Howell-Jolly bodies |
microcytosis |
poikilocytosis |
polychromatophilia |
increased neutrophil cell number |
increased granulocyte number |
thrombocytosis |
increased mean platelet volume |
giant platelets |
decreased B cell number |
increased lymphocyte cell number |
increased monocyte cell number |
decreased leukocyte cell number |
increased leukocyte cell number |
reticulocytosis |
decreased hematopoietic stem cell number |
increased hematopoietic stem cell number |
abnormal spleen morphology |
abnormal spleen red pulp morphology |
increased spleen red pulp amount |
abnormal spleen white pulp morphology |
decreased spleen white pulp amount |
spleen fibrosis |
abnormal hematopoietic system physiology |
abnormal bone marrow cell physiology |
enhanced megakaryocyte emperipolesis |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2m1Dlbr/Jak2m1Dlbr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1.1Jlvl/Jak2tm1.1Jlvl | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1.1Kuw/Jak2tm1.1Kuw | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1Jni/Jak2tm1Jni | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1Kf/Jak2tm1Kf | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1Kpf/Jak2tm1Kpf | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm2.1Kpf/Jak2tm2.1Kpf | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2m1Dlbr/Jak2+ | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2m1Dlbr/Jak2tm1Jni | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1.2Ble/Jak2+ | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1Jni/Jak2+ | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1Kf/Jak2+ | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm2.2Jlvl/Jak2+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg(H2-Kb-Jak2*V617F)2Shmd/0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1Mohi/Jak2tm1Mohi Tg(Mx1-cre)1Cgn/0 (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1.1Ble/Jak2+ Commd10Tg(Vav1-icre)A2Kio/Commd10+ (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1(JAK2)Argr/Jak2+ Dppa3tm1(cre)Peli/Dppa3+ (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1(JAK2)Argr/Jak2+ Tg(Mx1-cre)1Cgn/0 (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm1Mohi/Jak2+ Tg(Mx1-cre)1Cgn/0 (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jak2tm2.1Jlvl/Jak2+ Tg(Vav1-cre)#Cgp/0 (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools